What do you mean safe to use? I will tell you like this, I tried a few but results were nothing spectacular. They can help a bit, but there are better ways for saving battery yourself. Screen, 3G, WiFi, GPS and such are the biggest energy wasters. So you can do a lot just by lowering the brightness a bit and turning wireless modules off when you don't need them.
If you are lazy battery saver can save some like automatically turn off some stuffs like wifi, gps, screen brightness etc. Only way you can save battery by using custom kernel and tweak cpu according to your need.
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